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., 2000) afforded new methods to the elucidation of CB receptor mediated consequences. Numerous studies have shown an analgesic outcome with synthetic and endogenous cannabinoids in inflammatory soreness designs (such as Jaggar et al

This result was prevented by co-administration on the CB1 receptor antagonist SR141716a, but not by co-administration on the CB2 receptor antagonist SR144528, suggesting this motion of WIN55,212-two is mediated via

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3 tests of hind limb withdrawal to thermal, chilly and mechanical stimuli had been employed in this examine. Every test was repeated on equally the operated hind paw and also the contralateral hind paw with all sensory tests carried out by a ‘blinded' investigator.

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A beneficial reaction was recorded In case the animal withdrew the paw subsequent software. For each measurement, the paw was sampled 5 instances in addition to a suggest calculated. At the least 3 min elapsed involving Each and every exam.

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